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Rapid-Acting Insulin Analogues
Rapid-Acting Insulin Analogues
Mojtaba Malek, MD
Associate Prof. of Endocrinology and Metabolism
Tehran University of Medical Sciences
Institute of Endocrinology and Metabolism
Endocrine Research Center
(Hemmat Campus)
AGENDA
- Introduction
- Pharmacokinetic Properties of Insulin
- Molecular Structure
- Lispro
- Glulisine
- Aspart
- Comparison between Insulin Regular & Rapid-Acting Insulin in DM1
- Comparison between Insulin Regular & Rapid-Acting Insulin in DM2
- Rapid –Acting Insulin in Pregnancy
- Rapid –Acting Insulin in Elderly
- Conclusion
- After SQ injection regular insulin tends to dissociate from its normal hexameric form, first into dimers and then monomers.
- Only dimeric & monomeric forms can pass through the endothelium.
- The resulting delay in the onset and duration of action, limits its effectiveness in controlling postprandial glucose.
- Dose dependent pharmacokinetics, with prolonged onset, peak, duration of action with higher doses.
